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GLP-1, which stands for glucagon-like peptide-1, is a hormone integral to the regulation of appetite and blood sugar control
Figure 1 illustrates the progression from endogenous peptide discovery through receptor identification, physiological validation, pharmacologic engineering, and clinical translation
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Cost and insurance coverage are major barriers: these drugs are expensive, branded biologics, and many insurers impose strict criteria (e.g., documented failure of lifestyle therapy, presence of comorbidities, high BMI thresholds) before approval
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