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The primary study (NCT03616821) was a 54-week double-blind, placebo-controlled Phase 2 RCT evaluating brazikumab versus placebo in 242 participants with moderately to severely active UC, measuring clinical remission at week 10 as the primary endpoint along with safety parameters through week 68

Oral Bioavailability Challenges A frequently cited 2015 randomized controlled trial published in the European Journal of Nutrition (N=54) found that oral glutathione supplementation at 250 mg/day and 1,000 mg/day for 6 months increased body stores of GSH by 30% to 35% compared to placebo, as measured in erythrocytes and buccal cells [6]

Le is triple board-certified and trained at the University of Utah and McGovern Medical School

Always dispose of needles after one use, and do not share needles or pens with anyone