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The dark blue circles in the terminal portion of tirzepatide are amino acids from exenatide, a protein-derived peptide (exendin-4) present in the venom of the Gila monster ( Heloderma suspectum ) and known to activate the receptor GLP-1

Many trials report only aggregate lean mass changes without distinguishing between muscle, organ, or fluid components, limiting insights into the functional and metabolic consequences of weight loss [69, 77]

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These findings highlight a clear pattern: Ozempic can cause not only fat loss, but also a meaningful reduction in lean muscle tissuesometimes up to one-third or more of the total weight lost