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(2020) 158:123249.e3

Recent experiments have shown that supplementation with nicotinamide mononucleotide (NMN) significantly elevates the intracellular levels of NAD(H) and nicotinamide adenine dinucleotide phosphate during in vitro fertilisation (IVF) of bovine oocytes, enhances the development of oocytes to the blastocyst stage, and regulates the expression of genes related to mitochondrial function

The optimized formulation was intranasally administered in rats with rotenone-induced PD animal model, motor function and coordination were investigated besides testing the levels of different biomarkers and histopathological examination

This pattern warrants reassessment rather than automatic dose escalation