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GIPRs are abundantly expressed on -cells, and their activation induces a rise in cAMP and intracellular calcium levels, facilitating glucose-dependent insulin release from pancreatic -cells (118)

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and in those with BMI 30 kg/m 2 regardless of the presence of cardiometabolic risk factors

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Although GLP-1 analogs were initially characterized as antidiabetic agents, they are increasingly being recognized as anti-obesity agents

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