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Tissue perfusion and sexual function pathways A case report of female anorgasmia and hypoarousal temporally related to GLP-1 agonist use (including semaglutide after a switch from liraglutide) proposed mechanisms including smooth-muscle vasoconstriction with reduced genital blood flow and central neurotransmitter pathway effects (hypothalamic signalling)

The idea that having to take a drug consistently for its best effects is nothing new

(2025) shows 50% frequency dosing retains approximately 72% of weekly dosing weight loss outcomes

Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function