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These aren't minor gaps, they represent the entire translational bridge that would need to be built before canine research could meaningfully extend the rodent findings

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Table 2G A review of preclinical studies of GLP-1 and GLP-1RAs in stroke

The EMANATE (NCT05093634) trial is a multicenter, phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of setmelanotide in individuals aged 6 to 65 years with obesity due to rare heterozygous variants in genes involved in the melanocortin-4 receptor (MC4R) pathway