glp-1 fatty liver Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression Does GLP-1 Help Fatty Liver?

- Opportunity for new delivery formats (oral, depot injectables)

A phase I/II clinical trial found that the most common side effects were mild and transient (Teichman et al., 2006): Injection site reactions (redness, mild swelling) Headaches Flushing or warmth Temporary water retention Joint tightness or tingling Transient fatigue or dizziness Serious adverse events are rare when the peptide is used under medical supervision at appropriate doses

A gradual decline in the level of LPO was observed in this study following day 1 to day 30

Mosenzon O, Alguwaihes A, Arenas Leon JL, Bayram F, Darmon P, Davis T, et al