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The organic concentration of carnitine is a result of several metabolic pathways such as ingestion, endogenous synthesis, transport and elimination, which may be altered by diseases leading to carnitine deficiency and impaired lipid metabolism
The primary reason a medication is put on a deferral list is that it could potentially harm a recipient (such as a pregnant woman or a person with a compromised immune system) or because it suggests an underlying condition that makes donation unsafe for the donor
This is actually one argument in favor of microdosing , where gastrointestinal effects are minimized while anti-inflammatory receptor activation may still occur
Regular TSH monitoring every 6-8 weeks during initial treatment helps identify whether dose adjustments are needed
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