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Deficiency can be due to inadequate dietary intake, especially in vegans, but is otherwise more likely due to problems with absorption, which is more complex than that of other vitamins

The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework

[1] [2] This triple-receptor mechanism distinguishes it from currently approved agents such as semaglutide (a GLP-1 agonist) and tirzepatide (a dual GIP/GLP-1 agonist)

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