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One of these trials also assessed anxiety symptoms and found no effect of liraglutide compared with placebo over 26 weeks in 80 patients with comorbid T2DM and obesity who had previously undergone bariatric surgery 186

In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)

It is essential to be patient and allow your body time to adjust to Wegovy

The primary difference lies not in how the drug works, but in how the body's overall metabolic state is managed alongside treatment