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Secondly, FAPa + fibroblasts are almost undetectable in non-inflammatory conditions, while they significantly increase in inflamed synovial membranes, and the synovial inflammatory milieu tends to promote ferroptosis and lipid ROS production, and induction of ferroptosis is effective in reducing the number of FLSs and thereby improving RA
A., Roy, W
The American Medical Society for Sports Medicine (AMSSM) emphasizes the importance of quality control in regenerative medicine, noting that lack of precise control and biological characterization can impede clinical outcomes and pose safety risks
Safety considerations include pregnancy and breastfeeding status, existing medical conditions, and concurrent medicines
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