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The temptation to escalate the dose because nothing is happening yet is exactly the mistake the timeline section is designed to head off the mechanism is cumulative, not dose-chased
Usually weekly for the first month, then every 24 weeks depending on your response and baseline levels
After that it slowly disappeared because it became more and more difficult to obtain radioactive B12 suitable for human use, and at the same time less and less acceptable to use radioactive B12 in a diagnostic test
This applies even if the solution still looks clear and the vial has been stored perfectly
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