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Further, fibrotic ECM is known to contribute to the increased stiffness of fibrotic tissues, and this stiffness is essential for sustained TGF responses as stiff ECM induces mechanical strain and can help position latent TGF near MMPs, facilitating the liberation of active TGF (31, 249)

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36 Several other recent studies also confirmed that tirzepatide treatment is superior to other GLP-1 RAs and placebo in promoting meaningful weight loss

Potential candidates for medical weight loss at Klinic include adults with a BMI of 30 or higher, or 27-plus with other weight-related conditions