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If levels don't respond to standard supplementation, investigate possible MTHFR polymorphisms, malabsorption conditions like celiac or Crohn's disease, or potential medication interactions

Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder

& Mercurio, A

Immunostaining revealed mixed cell populations with many undifferentiated hPSCs and mesoderm cells, and DE markers SOX17 and FOXA2 were expressed at lower levels compared to the Activin A-based control (CA)