One study examining the effects of the GLP-1 liraglutide, for example, found that the medication improved insulin sensitivity within two weeks, prior to weight loss, in people who have obesity and prediabetes, but other research has found that GLP-1s only have minimal direct benefits on insulin sensitivity
News-Medical+3EurekAlert!+3ASMBS+3 To put numbers on it: Surgical patients lost ~58 lbs in two years ( 24% of total body weight, or TBW) GLP-1 patients lost only ~12 lbs ( 4.7% TBW) over the same period EurekAlert!+2News-Medical+2 Even among GLP-1 users who continued therapy for a full year, weight loss averaged only ~7% TBWstill far less than surgical outcomes EurekAlert!+2ASMBS+2 Another rigorous analysis published in JAMA Surgery compared weight loss surgery and GLP-1 receptor agonists over two years
He says that decreased skin elasticity is often seen with insubstantial vitamin and mineral intakeand that becomes common among those who limit their diet. But there may be other factors at play that are more specific to GLPs, say experts
The regular vitamin D metabolic profiles illustrated with either wild-type mouse VDR or VDR null mice transgenic for the wild-type human VDR, but not the ligand binding-defective form of the protein, this suggests the essential roles of VDR on VD metabolism 25