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In a mouse model of middle cerebral artery occlusion (MCAO), M1-type microglia significantly exacerbated vascular endothelial injury and blood-brain barrier (BBB) disruption after ischemic stroke by secreting the pro-inflammatory factor TNF-

The formulated nanoparticles significantly attenuated t-BOOHinduced cytotoxicity across multiple brain-derived cell lines and exhibited superior permeability across an in vitro BBB model (Papp 80 10 6 cm/s) relative to unencapsulated phytoconstituents (Papp 50 10 6 cm/s) (152)

They activate different second messenger systems

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