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Whilst GLP-1 receptor activation can exert multiple direct neuroprotective effects, the protective influence of GLP-1 receptor agonists may occur indirectly through the restoration of the dysfunctional insulin signaling associated with neurodegenerative disease

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Nonetheless, liraglutide is contraindicated for patients having a familial or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (which includes medullary thyroid carcinoma as one component) [59]

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