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There are also subsets of adipocytes that remain stable and non-responsive to most external stimuli, leaving their lipid reserves relatively unchanged, or even increased, under conditions such as caloric restriction and exercise 2,3,4,5,6,7

In addition to glucose, an increased influx of glutamine into cells has been linked to the development of resistance to chemotherapy and endocrine therapies by activating pathways that support both survival and proliferation [16]