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The key structural modification is a C18 fatty diacid chain attached at position 26 (lysine) via a linker, which enables non-covalent binding to albumin in the bloodstream

Side effects can be managed through dietary modifications (smaller meals, avoiding high-fat foods), adherence to dose escalation schedules, and appropriate hydration

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Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, Busha AI: N-acetyl cysteine as a glutathione precursor for schizophreniaa double-blind, randomized, placebo-controlled trial