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Peripheral IR primarily involves reduced insulin-mediated glucose uptake by skeletal muscle and adipose tissue, driven by defects in the insulin receptor substrate and downstream signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), leading to diminished translocation of glucose transporter type 4 (SLC2A4/GLUT4) and glucose uptake [5]
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De plus, nous avons mesur les activits leucocytaires et rythrocytaires des enzymes lies au GSH, telles que la glutathion rductase (GR), la glutathion-S-transfrase (GST) et la glucose-6-phosphate dshydrognase (G6PD), et estim linfluence de ladministration de NAC sur lintensit du stress oxydatif, qui a t mesure comme le niveau de lipofuscine (LPS) dans les rythrocytes
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