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The molecular design principles that enable this extended half-lifeincluding the C18 fatty acid chain, which confers strong albumin binding, and amino acid substitutions that confer DPP-4 resistancewere elucidated during the development of semaglutide (Lau et al., 2015)
Semaglutide is the active ingredient in the brand-name drugs Ozempic, Wegovy, and Rybelsus , all of which are also made by Novo Nordisk
Research interest in this peptide centers on its selectivity: it does not appear to elevate IGF-1 levels in studied models, distinguishing it mechanistically from full growth hormone
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