The 2026 Expert Breakdown You Need Let's cut right to the chase
In vitro studies on bone cells supported the expression of the conventional GLP-1R in osteoblasts and confirmed that liraglutide, at nanomolar concentrations, promoted osteoblast differentiation and reduced osteoblast apoptosis via activation of the PI3K/Akt/GSK3K, MAPK, and cAMP/PKA/-catenin intracellular pathways [46,47,48]
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Anesthesia providers were not advised to consider the indication for GLP-1RA or the potential harm of holding the medication, in particular for patients taking this class of medications to treat diabetes. He added, The ASAs suggestions were having a real impact on patient care, and many gastroenterologists and endoscopists were reaching out with questions regarding how to care for patients taking GLP-1 agonists who require endoscopic procedures. Wang and colleagues suggested that patients prescribed GLP-1s who follow the standard perioperative procedures, including an 8-hour solid food fast and a 2-hour liquid diet fast without symptoms of nausea, vomiting, dyspepsia or abdominal distention, could proceed with endoscopy