Lowest semaglutide payload within the formulations was detected for SEDDS 3 containing HIP (6.3 0.2 mg/mL
Stability Study Protocol Guideline:ICH Q1A(R2) Stability Testing, ICH Q1B Photostability Protocol No.:STAB-SM10-2026-01 Batch No.:COA-SM10-8380 Packaging:Amber glass vial, PTFE-lined cap, N backfill, secondary PE bag + desiccant Accelerated Conditions:40C 2C / 75% RH 5% RH (ICH Zone IVb) Long-term Conditions:25C 2C / 60% RH 5% RH Photostability:ICH Option 2: 1.2 million luxhours + 200 Wh/m near-UV Parameters Monitored:Appearance, Assay (HPLC), Impurities, Moisture (KF), Sterility Timepoints:0, 1M, 2M, 3M, 6M (accel.)
As of December 2025, Retatrutide remains investigational and is not approved for any indication
Small molecule dipeptidylpeptidase IV inhibitors under investigation for diabetes mellitus therapy