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By week 4, many of these patients have moved from significant functional impairment from GI symptoms to largely resolved or substantially reduced symptom burden
CDC and FDA guidance say otherwise
It is one of the first inflammatory signals released when the immune system perceives a threat, and in psoriasis, it acts as a master switch that amplifies virtually every other inflammatory pathway involved
And it needs to be baked into protocol recommendations from the start, not saved for later once the kill phase is over
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