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Compliant blood vessels absorb the pulse of each heartbeat more smoothly, reducing the pressure peaks that stress arterial walls over time
Chondrocyte dedifferentiation was majorly characterized as the reduced expression of COL2 and ACAN and enhanced expression of type I collagen and versican ( COL2 expression, but not ACAN ( In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function
PMID 16352683
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