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A separate JAMA Health Forum analysis found semaglutide would need a very large price reduction to meet common cost-effectiveness thresholds, and tirzepatide would also require further price cuts to become cost-effective in that model
The underlying pathogenesis is due to an allergic cutaneous manifestation resulting from an exaggerated immune response to external stimuli
However, semaglutide has also been associated with more severe side effects, including an increased risk of thyroid C-cell tumors in animal studies, pancreatitis, and diabetic retinopathy complications
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