Key Takeaways Mechanism of action: Triple-hormone agonist targeting GLP-1, GIP, and glucagon receptors Efficacy: 24.2% average weight loss in 48 weeks UK availability: 2026 (UK), potentially 2027 (FDA) Common side effects: Nausea, diarrhoea, vomiting, constipation Safety profile: Similar to existing GLP-1 medications but with concerns about rapid weight loss By entering I agree to the Terms and Conditions
And so that operation produces about a 25% reduction in body weight in one year
if more than 3 days, skip that dose Daily GLP-1s: If you miss a dose, follow your PIL instructions If you take insulin or sulfonylureas alongside GLP-1 medications, do not adjust these doses yourself without medical advice, as this could increase hypoglycaemia risk Report persistent side effects to your GP rather than stopping treatment abruptly Some patients may require dose adjustment if they develop acute illness, undergo surgery, or experience significant changes in kidney function
Patients should work with healthcare providers or registered dietitians to ensure nutritional adequacy during weight loss