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The role of environmental factors in ASD became evident with the observation that advanced paternal and maternal age is associated with an increased likelihood of having a child with ASD (Johnson et al., 2007), neocortical anomalies, macrocephaly in early life, and altered trophic signaling, all consistent with atypical neurodevelopmental trajectories (McCaffery and Deutsch, 2005)

Grape seed extract provides polyphenols that also provide antioxidant support for the retina

10.1016/j.healun.2007.04.006 J Heart Lung Trans

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