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Continuous data collected from the participants over the 26 week treatment period was assessed using an ANCOVA model, using randomized treatment as a factor and baseline bodyweight as a covariate

For the earlier window mild cognitive impairment (MCI) and brain aging where synaptic loss is the dominant driver of symptoms and where the 2026 NICE rejection of lecanemab and donanemab has left a substantial UK treatment gap, the synaptic-rationale conversation continues even after the fosgonimeton failure

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