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Disease Prevention Cancer There has been considerable research on the effect of selenium supplementation on the incidence of cancer using preclinical models

The effect varies from person to person and typically depends on dosage, underlying health conditions, and genetic factors

Although certain NER gene mutations (ERCC6-Q524* and ERCC4-A583T) were found to be functionally associated with platinum sensitivity in vitro, these NER alterations did not affect HR or confer sensitivity to PARPis

Based on the establishment and development of the theory of the pathological roles of free radicals, the role of GPxs has gradually attracted researchers attention, and the involvement of GPxs in the occurrence and development of malignant tumors has been shown