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revealed that empagliflozin improved cardiomyocyte stiffness and diastolic dysfunction by reducing inflammation, oxidative stress and protein kinase GI (PKGI) oxidation and polymerization in human and murine HFpEF [104]
GLP-1RA/tesaglitazar depends on functional GLP-1R and shows preserved effects in db/db mice When given at a daily dose of 50 nmol kg 1 , 6 days of treatment with GLP-1RA/tesaglitazar robustly improved body weight, fat mass, food intake, blood glucose and glucose tolerance in DIO wildtype mice (Fig
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