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The pharmacokinetics of retatrutide are dose-proportional, with a half-life of approximately 6 days, making weekly dosing feasible [113]
Despite the fact that the drug is not FDA approved for chronic weight loss, doctors seem to be prescribing it off-label to help people shed pounds
Gastrointestinal effects are the most frequently reported and include: Nausea (particularly during dose escalation) Vomiting Diarrhoea and constipation Abdominal discomfort These effects are generally transient but can be distressing and may affect nutritional intake
Discussion The global diabetes epidemic, affecting approximately 828 million adults in 2022 32 , has driven widespread adoption of GLP-1 RAs due to their dual glycemic and weight management benefits 33,34,35
