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Patients included in the trial had HbA1c 7 to 10% and were treated with either: diet and exercise alone or 1 to 3 oral antidiabetic drugs (metformin, sulfonylurea, glitazone or sodium-glucose co-transporter 2 inhibitor)
While there's no upper limit to how much vitamin B12 you can take, there are general dosage recommendations
Five studies could not be included in the quantitative synthesis because they did not report depressive-symptom outcomes with the summary statistics needed to calculate the effect size
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