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Kristin Lovato, an obesity specialist at Banner Health, says she has seen how rapid weight loss affects physical conditioning

Although GLP-1RAs are generally well tolerated, there are some circumstances in which this drug class is not recommended

Retatrutide activates three hormone receptors at once: GLP-1R (reduces appetite, stimulates insulin), GIPR (boosts insulin and modulates appetite via a separate brain pathway), and GCGR (increases calorie burning and fat breakdown)

Glaucoma is one such disease, characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy, leading to progressive and permanent vision loss