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This may make these medications challenging or unappealing to some individuals, as the medications need to be refrigerated and injected subcutaneously (under the skin)
Like other peptide drugs, it is highly susceptible to degradation by digestive enzymes in the gastrointestinal tract
Such studies have shown BBB dysfunction in patients with AD and other neurodegenerative disorders such as PD, ALS, and MS, which is also supported by biofluid biomarker data and postmortem studies [190]
In line with that, in a previous study investigating extracellular glutathione depletion in cells lacking gshA , ggt , and gsiAB, glutathione accumulation in the cells was not completely absent, however drastically reduced (Suzuki et al., 2005)
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