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In addition, they also observed that the serum levels of type II collagen-specific immunoglobulin G (CII-IgG) and proinflammatory cytokines IL-6 and CXCL1 were decreased, whereas those of the anti-inflammatory cytokine IL-10 were increased

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Critically, Ta1 also works through an indoleamine 2,3-dioxygenase (IDO) dependent pathway that can attenuate the inflammatory activity of dendritic cells