essence study semaglutide In an interim analysis of a phase 3 trial involving 800 patients with metabolic dysfunction–associated steatohepatitis, once-weekly improved liver histologic results at 72 weeks. Full trial results and Research Semaglutide Improves Histology in MASH:

This mechanism of action differs from that of sulfonylurea derivatives, which stimulate insulin release even at low blood glucose concentrations, which is fraught with the development of sulfonylurea-induced hypoglycemia not only in patients with type 2 diabetes mellitus, but also in healthy individuals

The combination appears to enhance: Appetite reduction Metabolic regulation Fat burning and energy expenditure Because of this triple mechanism, researchers believe Retatrutide may be able to produce greater average weight loss than single pathway medicines, but research is still ongoing

10.1007/s00394-021-02674-1 Eur J Nutr

In theory, this could increase the risk for adverse effects and toxicity