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miR-124 further modulates immune homeostasis by normalizing HG-induced microglial hyperactivity, suppressing inflammatory mediators (e.g., Tnf-, Ccl2, Ccl3), and downregulating transcription factors (PU.1) and lipid raft proteins (Flot1), thereby preventing vasoregression and neuroretinal dysfunction (48)
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This review synthesizes evidence positioning host and microbial melanin as the key signaling molecule of the melanocortin pathway, which is inherently circadian-regulated, governing metabolic and immune homeostasis across the gut-brain-skin axis
Central Nervous System Effects: Additionally, GLP-1 receptors are found in various regions of the brain involved in appetite regulation and food intake
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