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Rendering of Eli Lilly's new facility in Alabama (Credit: Eli Lilly) Eli Lilly earmarks $6B for GLP-1 pill factory in Alabama Eli Lilly will spend $6 billion to build an orforglipron factory in Huntsville, AL, the third of four new US sites the pharma giant plans Sign up to read this article for free

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Para los millones de personas con diabetes tipo 2 que desean un tratamiento oral que se pueda tomar de manera sencilla en cualquier momento del da, orforglipron tiene el potencial de ser una opcin teraputica atractiva para la primera lnea de tratamiento en Atencin Primaria. En los tres ensayos clnicos , el GLP-1 oral de Lilly mostr mejoras clnicamente significativas respecto a los datos basales en factores clave de riesgo cardiovascular, incluyendo colesterol no HDL, colesterol HDL, colesterol VLDL , colesterol total, presin arterial sistlica y triglicridos

Exclusion criteria included previous GLP-1 RA use within 24 weeks, diabetes mellitus, significant alcohol use of 3 months within 90 days prior to screening (consuming 5 alcoholic drinks for men or 4 for women during a single occasion or 3 drinks on 4 mor more days of the week on average for men or 2 drinks on 4 or more days of the week on average for women), other causes of liver disease, known active hepatitis C virus infection defined as a detectable HCV RNA within 24 weeks prior to study entry, and active/chronic hepatitis B defined as a positive hepatitis B surface antigen (HBsAg) at screening