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Instead of acting locally on the skin, its introduced systemically, usually in small doses injected under the skin
In a trial by Iepsen et al., 37 women with an average age of 46 (Standard Deviation: 2 years, range 18-65 years) and BMI of 34 (SD: 0.5 kg/m 2 ) achieved a 12% weight loss after 8 weeks of low-calorie diet modifications
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton
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