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Given the pivotal role of IR in glucotoxicity and lipotoxicity, therapies that modulate incretin pathways, particularly glucagon-like peptide-1 (GLP-1) receptor agonists, may attenuate hepatic DNL and improve peripheral insulin sensitivity indirectly through weight loss, enhanced glycemic control, and reduced inflammatory tone [34]
the tablet is taken once a day
308 The absence of EF-hand domain family member D2 (EFHD2), improves hepatic steatosis, reduces immune cell infiltration, suppresses ferroptosis caused by lipid peroxidation, and ultimately reduces MASH
Pregnancy and planned pregnancy are also contraindications, and patients should stop these medications well before any planned pregnancy
