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(2008) Treatments for spinal cord injury: Is there hope in neurosteroids

Historically, first-line systemic ADT mostly took the form of chemical castration through gonadotropin releasing hormone (GnRH) agonists and antagonists, which reduce testosterone levels by suppressing androgen secretion from the testes [4, 7, 8]

In UK practice, NICE guidance recognises these benefits, though SGLT2 inhibitors are typically prioritised for cardiorenal protection, with GLP-1 receptor agonists with proven cardiovascular benefit considered when SGLT2 inhibitors are unsuitable