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Controversy exists on whether GLP-1Rs exist on pancreatic cells, with evidence pointing to an indirect effect of GLP-1RAs on glucagon inhibition

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Phase 2 dose-finding trials evaluated subcutaneous doses of 0.75 mg, 1.25 mg, and 1.75 mg administered as needed over 12 weeks

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Collectively, these studies support the versatile antibacterial potential of CQDs through various mechanisms, however, most evidence remains derived from in vitro systems, with limited in vivo validation and safety profiling, highlighting the need for further evaluation prior to clinical translation

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