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10.1016/j.bbagen.2009.06.003 246 PrezV
The National Cancer Institute conducted chemoinformatics analysis of 60 cell lines and showed a negative correlation between xCT expression levels and sensitivity to compounds associated with GSH-mediated resistance, which indicated that xCT expression induces chemoresistance via GSH-mediated ROS detoxification activity (82)
Cardiovascular tissue, with similarly high metabolic demand, became an obvious target
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