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doi: 10.1007/s13555-018-0278-6
128 Cyclosporine has been identified as a substrate for CYP3A4, P-glycoprotein (P-gp), and organic anion transporting polypeptides (OATPs), while also acting as a potent inhibitor of CYP3A4, multidrug resistance-associated protein 2 (MRP2), OATPs, P-gp, and breast cancer resistance protein (BCRP)
Following the gradual dosing schedule helps minimize these effects significantly
Laboratory markers often show measurable shifts: fasting glucose improves, insulin resistance indicators decline, and inflammatory markers may decrease
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