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A 500-calorie diet is roughly a quarter of what an average adult needs, and running it for weeks risks gallstones, electrolyte imbalance, muscle loss, and heart rhythm problems

Testimonials reflect personal experiences and may not represent typical outcomes

Programs on the triple GIP/GLP-1/glucagon receptor agonist retatrutide and on the amylin analogue cagrilintide represent adjacent lines of investigation in the same pharmacological family, and researchers tracing the field often read them together

Still, the same substudy reported absolute lean mass reductions of several pounds in some arms, a reminder that any large caloric movement carries lean tissue with it unless training and protein intervene