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This ApoE-dependent interaction triggers severe oxidative stress and inhibits tumor growth (59)

For example, in a thioacetamide-induced mouse model, semaglutide reduced biochemical and histological markers of liver injury, attenuated -SMA expression, decreased oxidative stress, and downregulated the canonical TGF-/Smad signalling pathway while upregulating SIRT1 and phosphorylated AMPK

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Frontiers and new Horizons in Amino Acid Research 48 HashimotoW.SuzukiH.NoharaS.KumagaiH