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Patients should be aware that if they experience concerning symptoms whilst taking B12 supplements, they should discuss this with their GP and report suspected adverse reactions via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk)
Learn more and arrange a follow-up at Tonum research and follow-up services
Oral administration faces hepatic first-pass metabolism, reducing bioavailability to approximately 4050% of subcutaneous routes, but offers convenience for longer-term studies where daily injections create compliance challenges
This makes it of particular interest in studies targeting body recomposition and long-term metabolic efficiency, where muscle retention is critical for sustaining basal metabolic rate
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