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2013 Oct;33(5):627-35
If a patient experiences significant nausea after increasing the dose, they can drop back to the previous level the very next day
For individuals with pre-existing IBS , these gastrointestinal effects may overlap with or potentially worsen existing symptoms
A mechanism of action phase 1 study showed that the glycemic efficacy of tirzepatide in T2DM results from concurrent improvements in key components of diabetes pathophysiology, including -cell function, insulin sensitivity, and glucagon secretion (135)
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